Until recently it was primarily THC that was studied scientifically for its efficacy on nausea and vomiting. Recently there has also been attention for other cannabinoids. There are indications that the cannabinoids CBD, CBDA, THCA and CBDV have a therapeutic effect against nausea and vomiting.
Anecdotal evidence and preliminary scientific research indicate that the acid form of CBD (CBDA) helps against nausea and vomiting. This is good news, because unlike THC, CBDA has no psychoactive effect (which is also true for CBD). CBDA is naturally present in plants of the cannabis family and can also be found in Full Spectrum hemp oil.
In a study that considered the effects of CBDA it was found that the effects of metoclopramide (a drug against nausea) were improved by CBDA . The same was found for the drug ondansetron in another study .
CBD and THC
CBD and THC can also be used in combination. Duran and co-workers investigated Savitex as a remedy for nausea and vomiting in patients undergoing chemotherapy . Savitex is a drug that contains THC and CBD in approximately equal amounts (a ratio of 1:1). Patients were administered Savitex in addition to the usual medication for nausea. There was also a control group that received a placebo instead of Savitex. The results were as follows: 57% of the Savitex group didn’t experience nausea, compared to 22% of the placebo group. When we look at vomiting, 71% of the Savitex group experienced no problems, compared to 22% in the placebo group. The results of this study indicate that a combination of THC and CBD can help against nausea and vomiting.
For other non-psychoactive cannabinoids, such THCA and CBDV there are also indications that they help prevent nausea and vomiting [2,4]. Like CBD and CBDA these components are naturally present in plants of the cannabis family and can also be found in Full Spectrum hemp oil.
Advice for the use of cannabinoids against nausea and vomiting
Use a so-called Full Spectrum oil, which is an oil which that contains a whole spectrum of cannabinoids. You may also want to use THC in addition to this full spectrum oil. However, be very aware of the psychoactive effect that THC has. Based on scientific research, there is evidence that these cannabinoids are effective against nausea and vomiting: CBD, CBDA, THC, THCA and CBDV. Click here to read more about safe use of cannabinoids.
- Rock, E.M., Parker, L.A. (2013). Suppression of lithium chloride-induced conditioned gaping (a model of nausea-induced behaviour) in rats (using the taste reactivity test) with metocolpramide is enhanced by cannabidiolic acid. Pharmacol Biochem Behav, 111:84-9
- Rock, E.M., Parker, L.A. (2013b). Effect of low doses of cannbidiolic acid and ondansetron on LiCl-induced conditioned gaping (a model of nausea-induced behavior) in rats. Br J Pharmacol, 169(3): 685-92
- Duran, M., Pérez, E., Abanades, S. et al. (2010). Preliminary efficacy and safety of an oromucosal standardized cannabis extract in chemotherapy-induced nausea and vomiting. British Journal of Clinical Pharmacology, 70:656-63
- Rock, E.M., Kopstick, R.L., Limebeer, C.L., Parker, L.A. (2013a). Tetrahydrocannabinolic acid reduces nausea-induced conditioned nausea in rats and vomiting in Suncus Murinus. British Journal of Pharmacology, 170(3):641-648